Table 2. Medications to WITHHOLD Prior To Surgery**
BIOLOGICS: WITHHOLD
these medications
through surgery Dosing Interval
Recommended timing
of surgery since last
medication dose
Infliximab (Remicade) Every 4, 6, or 8 weeks Week 5, 7, or 9
Adalimumab (Humira) Every 2 weeks Week 3
Etanercept (Enbrel) Every week Week 2
Abatacept (Orencia) Monthly (IV) or weekly
(SQ)
Week 5
Week 2
Certolizumab (Cimzia) Every 2 or 4 weeks Week 3 or 5
Rituximab (Rituxan) 2 doses 2 weeks apart every
4–6 months
Month 7
Tocilizumab (Actemra) Every week (SQ) or every 4
weeks (IV)
Week 2
Week 5
Anakinra (Kineret) Daily Day 2
IL-17-Secukinumab
(Cosentyx)
Every 4 weeks Week 5
Ustekinumab (Stelara) Every 12 weeks Week 13
Ixekizumab (Taltz)
†
Every 4 weeks Week 5
IL-23 Guselkumab
(Tremfya)
†
Every 8 weeks Week 9
JAK inhibitors:
WITHHOLD this
medication 3 days prior
to surgery*
Tofacitinib (Xeljanz) Daily or twice daily Day 4
Baricitinib (Olumiant)
†
Daily Day 4
Upadacitinib (Rinvoq)
†
Daily Day 4
