27
Galantamine (Razadyne,
Razadyne ER) $
Memantine (Namenda,
Namenda XR) $$$
Memantine HCl and
donepezil HCl (combo)
Namzaric $$$$
Mild to moderate
Alzheimer's dementia
Alzheimer's disease
(moderate to severe)
Moderate to severe
dementia of the Alzheimer's
type in patients stabilized
on 10 mg of donepezil
hydrochloride once daily.
Twice daily (Razadyne):
Start at 4 mg every 12 h,
increase to 8 mg every 12 h
aer 4 wk;
recommended dosage 8 or
12 mg every 12 h
Once daily (Razadyne
ER): Start with one 8 mg
capsule daily (preferably
with food) and increase to
16 mg/day aer 4 wk; may
increase to 24 mg/day aer
another 4 wk
Note: Galantamine also
available in oral solution
(4 mg/mL)
IR: Initial: 5 mg daily
increased by 5 mg daily
to a target of 10 mg twice
daily. Titrating no more
frequently than once every
7 days.
XR: 7 mg once daily
increasing by 7 mg daily
to a target of 28 mg daily.
Titrating no more frequent
than once every 7 days.
Initial: 7 mg/10 mg, taken
once daily in the evening
Max: 28 mg/10 mg
Defined as those occurring
at a frequency of at least
5% and at least twice the
placebo rate: Nausea,
vomiting, diarrhea and
anorexia
Diarrhea and dizziness See individual agents.
Headache, diarrhea, and
dizziness
7–8 60–80 See individual agents
Liver Partially hepatic Partially hepatic
Administer with food Administer without regard
to meals
See individual agents
18% 45% See individual agents
