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Possible Side Effects and Adverse Effects
Nasal irritation, sneezing, cough
For high volume nasal irrigations: ear fullness, irrigation fluid transmission to middle ear.
Increased appetite, weight gain, fluid retention, gastritis, sleep disturbance, restlessness,
anxiety, depression, aggressiveness, psychosis, adrenal suppression, cataracts, glaucoma,
hair/skin changes, easy bruising, acne, delayed wound healing, muscle weakness, change
in body fat distribution, immunosuppression, hypertension, hyperglycemia/diabetes,
osteopenia, osteoporosis, avascular necrosis of the hip, kidney stones
Discomfort/burning, epistaxis, dryness, crusting, foul taste, headache, sore throat
Gastrointestinal upset, bloating, stomach cramping, nausea, vomiting, diarrhea,
fungal infections, drug-drug interactions, photosensitivity, bone/teeth staining,
allergic reaction, anaphylaxis, C. difficile colitis, hepatic impairment, renal impairment,
antibiotic resistance, ototoxicity
For macrolides: cardiotoxicity
Irritability, anxiety, restlessness, sleep disturbance, hypertension, tachycardia, heart
palpitations, drug-drug interactions, tremors
In young children: tachycardia, seizures, loss of consciousness, death
Discomfort/burning, dependency, dryness, increased congestion, rhinitis
medicamentosa, hypertension, anxiety, tremors
Drowsiness, headache, dry mucous membranes, restlessness, anxiety, insomnia,
tachyphylaxis, urinary retention
Discomfort/burning, drowsiness, dizziness, epistaxis, dryness, crusting, foul taste,
headache, sore throat, sneezing, nausea
Behavior/mood alterations, agitation, depression, irritability, hallucinations, tremor,
suicidal thoughts and behavior
For zileuton: hepatotoxicity
Bleeding, infection, scarring, septal perforation, lacrimal system injury, hyposmia/
anosmia, vision changes or blindness, orbital injury, cerebrospinal fluid leak, intracranial
injury, major vascular injury
