23
Table 8. Racial/Ethnic Issues in Evaluation, Risk Decisions,
and Treatment of ASCVD Risk
Racial/Ethnic Groupings
Asian
Americans
a
Hispanic/Latino
Americans
b
Blacks Comments
Safety Higher
rosuvastatin
plasma levels
are seen in
Japanese,
Chinese,
Malay,
and Asian
Indians as
compared with
whites. FDA
recommends a
lower starting
dose (5 mg of
rosuvastatin in
Asians vs. 10
mg in whites).
Caution is
urged as dose is
uptitrated.
ere are no
specific safety
issues with
statins related to
Hispanic/Latino
ethnicity.
Baseline
serum CK
values are
higher in
blacks than
in whites.
e 95th
percentile
race/
ethnicity-
specific and
sex- specific
serum CK
normal levels
are available
for assessing
changes in
serum CK.
Clinicians
should take
Asian race into
account when
prescribing
dose of
rosuvastatin
(See package
insert). In
adults of East
Asian descent,
other statins
should be used
preferentially
over
simvastatin.
a
e term Asian characterizes a diverse portion of the world's population. Individuals from
Bangladesh, India, Nepal, Pakistan, and Sri Lanka make up most of the South Asian group.
Individuals from Japan, Korea, and China make up most of the East Asian group.
b
e term Hispanics/Latinos in the United States characterizes a diverse population group.
is includes white, black, and Native American races. eir ancestry goes from Europe to
America, including among these, individuals from the Caribbean, Mexico, Central and South
America.
