Treatment
12
Table 1. Drug Therapy for the Management of
Moderate to Severe CD
Drug Induction Maintenance
Biologic-
naïve
induction
Infliximab
✔ ✔ ✔*
Adalimumab
✔ ✔ ✔*
Certolizumab pegol
✔ ✔
Adalimumab + thiopurine vs
adalimumab monotherapy
✔
Infliximab + thiopurine vs
infliximab monotherapy
✔
Natalizumab
× ×
Ustekinumab
✔ ✔ ✔*
Vedolizumab
✔ ✔ ✔*
Oral methotrexate monotherapy
× ×
Subcutaneous or intramuscular
methotrexate monotherapy
✔ ✔
iopurine monotherapy
×
✔
Corticosteroids
✔
×
5-aminosalicylate/sulfasalazine
× ×
Antiobiotic monotherapy
Biologic monotherapy vs
thiopurine monotherapy
✔
Biologic agents in combination
with antibiotics vs biologic
monotherapy
* Over certolizumab pegol.
✔ = strong recommendation for; ✔ = conditional recommendation for;
× = conditional recommendation against; × = strong recommendation against
