AGA GUIDELINES Bundle (free trial)

Luminal and Fistulizing Crohn’s Disease - Moderate-Severe

AGA GUIDELINES Apps brought to you courtesy of Guideline Central. All of these titles are available for purchase on our website, GuidelineCentral.com. Enjoy!

Issue link: https://eguideline.guidelinecentral.com/i/1512411

Contents of this Issue

Navigation

Page 5 of 13

Treatment 6 Recommendations a Recommendation Statements Strength of Recommendation Certainty of Evidence 5A. In adult outpatients with moderate to severe CD who are naïve to biologics and immunomodulators, the AGA suggests the use of infliximab in combination with thiopurines for the induction and maintenance of remission over infliximab monotherapy. Comment: Based on indirect evidence, combination infliximab with methotrexate may be more effective over infliximab monotherapy. Conditional Moderate 5B. In adult outpatients with moderate to severe CD who are naïve to biologics and immunomodulators, the AGA suggests the use of adalimumab in combination with thiopurines for the induction and maintenance of remission over adalimumab monotherapy. Comment: Based on indirect evidence, combination adalimumab with methotrexate may be more effective over adalimumab monotherapy. Conditional Very low 5C. In adult outpatients with moderate to severe CD, the AGA makes no recommendation regarding the use of, ustekinumab or vedolizumab in combination with thiopurines or methotrexate over biologic drug monotherapy for the induction and maintenance of remission. No recommendation Knowledge gap 6. In adult outpatients with quiescent CD on combination therapy, the AGA makes no recommendation for withdrawal of either the immunomodulator or the biologic over ongoing combination therapy of a biologic and an immunomodulator No recommendation Knowledge gap 7. In adult outpatients with moderate to severe CD, the AGA suggests early introduction with a biologic with or without an immunomodulator rather than delaying their use until aer failure of 5-aminosalicylates and/or corticosteroids. Conditional Low

Articles in this issue

Archives of this issue

view archives of AGA GUIDELINES Bundle (free trial) - Luminal and Fistulizing Crohn’s Disease - Moderate-Severe