48
Special Populations
Table 17. Invasive Coronary Function Testing Definition and
Linked Pharmacotherapy for INOCA Endotypes
Endotype Disorder of Coronary Artery Function
Obstructive
CAD
>50% lesion by diameter stenosis in
epicardial artery >2.5 mm or a FFR ≤0.80
Noncardiac None Exclusion of diffuse or obstructive epicardial
coronary disease (FFR >0.8) without any of
the after abnormalities of coronary function:
CFR <2.0, IMR ≥25 or functional angina/
spasm during acetylcholine.
* Currently unavailable in the United States.
Modified with permission from Ford TJ, et al. J Am Coll Cardiol. 2018;72:2841-2855.
Copyright 2018 American College of Cardiolog y Foundation.
(cont'd)
6.1.3. HF With Preserved or Reduced Ejection Fraction
➤ CAD is the most common cause of HF in the United States and has
a pivotal role in the development and progression of both HF with
preserved ejection fraction and HF with reduced ejection fraction.
Management of patients with CCD and HF with preserved ejection
fraction and HF with reduced ejection fraction should follow
associated guideline recommendations for revascularization and
HF, as well as sections in this guideline: Section 4.2, "Guideline-
Directed Medical Therapy," Section 4.3, "Medical Therapy to Prevent
Cardiovascular Events and Manage Symptoms," and Section 5,
"Revascularization."
