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Class of Recommendations and Level of Evidence
Level of Value for Clinical Guideline Recommendations*
Level of Value
High value: Better outcomes at lower cost or ICER <$50,000 per QALY gained.
Intermediate value: $50,000 to <$150,000 per QALY gained.
Low value: ≥$150,000 per QALY gained.
Uncertain value: Value examined but data are insufficient to draw a conclusion because
of no studies, low-quality studies, conflicting studies, or prior studies that are no longer
relevant.
Not assessed: Value not assessed by the writing committee.
Proposed abbreviations for each value recommendation:
Level of Value: H indicates high value; I, intermediate value; L, low value; U, uncertain
value; and NA, value not assessed.
* Figures used in this table are based on US GDP data from 2012 and were obtained from
WHO-CHOICE Cost-Effectiveness resholds. http://www.who.int/choice/en/
Accessed June 3, 2022.
Reproduced with permission from Anderson JL, et al. J Am Coll Cardiol. 2014;63:2304-2322.
Copyright American Heart Association, Inc., and the American College of Cardiolog y.
