17
Bradycardias, conduction disorders, and use of pacing or
CRT in DM1 and DM2
COR LOE Recommendations
2a B-NR 4. In patients with DM1 or DM2 and marked first-degree AV
block (PR interval ≥240 ms) or intraventricular conduction
delay (native QRS duration ≥120 ms), PPM implantation is
reasonable if concordant with the patient's goals of care and
clinical status.
2a B-NR 5. In patients with DM1 or DM2 with HV interval ≥70 ms on EP
study, PPM implantation is reasonable if concordant with the
patient's goals of care and clinical status.
Atrial arrhythmias in DM1 and DM2
COR LOE Recommendation
1 B-NR 1. In patients with DM1 or DM2, anticoagulation according to
established guidelines and clinical context is recommended
for AF or AFL taking into consideration the risks of
thromboembolism and the risks of bleeding on oral
anticoagulation.
VAs, sudden cardiac death, and use of ICDs in DM1 and DM2
COR LOE Recommendations
1 B-NR 1. In patients with DM1 or DM2 in whom ICD therapy is
planned, an ICD system with permanent pacing capability is
recommended.
1 B-NR 2. In patients with DM1 or DM2, who are survivors of
spontaneously occurring hemodynamically significant sustained
VT or VF, ICD therapy is indicated if concordant with the
patient's goals of care and clinical status.
1 B-NR 3. In patients with DM1 or DM2 and an LVEF ≤35%, despite
GDMT, ICD therapy is indicated if concordant with the
patient's goals of care and clinical status.
1 B-NR 4. In patients with DM1 or DM2 in whom clinically relevant VAs
are induced during EP study, ICD therapy is recommended if
concordant with the patient's goals of care and clinical status.
2b B-NR 5. In patients with DM1 or DM2 in whom PPM implantation is
indicated, ICD therapy may be considered if concordant with
the patient's goals of care and clinical status.
(cont'd)
