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Cardiac Physiologic Pacing for the Avoidance and Mitigation of Heart Failure

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7 Table 2. CRT Response Criteria Response Criteria Clinical response 1. Reduction in mortality 2. Reduction in HF hospitalizations 3. Improvement in NYHA class 4. Improvement in quality of life, symptoms, or clinical composite scores 5. Increase in peak oxygen uptake (VO 2 ) (eg, >10%) 6. Improvement in 6-minute walk distance (6MWD) 7. Reduction in HF medications, such as diuretic therapy (note: continuation of guideline-directed medical therapy [GDMT] is advised) Echocardiographic response 1. Improvement or stability in LVEF (eg, ≥5% absolute increase or absence of worsening ) 2. Reduction in LV size (eg, reduction in LV systolic or diastolic dimensions or volume indices) 3. Increase in LV stroke volume 4. Reduction in mitral regurgitation Detection of electrical dyssynchrony-induced cardiomyopathy COR LOE Recommendations 1 B-NR 1. In patients who have substantial RVP that cannot be minimized with programming, periodic assessment of ventricular function is recommended to detect PICM. 2a B-NR 2. In patients with chronic LBBB, periodic assessment of ventricular function is reasonable to detect cardiomyopathy. Epidemiology, Pathophysiology, and Detection of Electrical Dyssynchrony-induced Cardiomyopathy

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