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Cardiac Physiologic Pacing for the Avoidance and Mitigation of Heart Failure

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40 Replacement or upgrade considerations COR LOE Recommendations 1 C-LD 1. In patients with HFimpEF, continuation of CRT with BiV pacing is recommended at the time of elective generator replacement. 1 C-EO 2. In patients who are thought to have benefited from CRT (including improvement, stabilization, or partial reversal of natural decline) in terms of symptoms, LVEF, or functional status, continuation of CRT with BiV pacing is recommended at the time of elective replacement based on patient- individualized risks and benefits of the procedure. 1 B-NR 3. In patients with CRT-D at the time of elective replacement, it is recommended that a decision for replacement vs revision to CRT-P should be based on patient-individualized risks and benefits of the procedure, and such shared decision- making should involve consideration of the previous response to CRT, appropriate implantable cardioverter-defibrillator (ICD) therapies for ventricular arrhythmias, continued risk of ventricular arrhythmias, inappropriate therapies, current lead performance factors, and the patient's overall goals of care. 2b C-EO 4. In patients with CRT or CSP where high lead pacing threshold contributes to rapid battery drain, implantation of a new lead may be considered after shared decision-making with the patient at the time of generator replacement to reduce the risk associated with frequent generator replacements. Troubleshooting for unfavorable response COR LOE Recommendations 1 C-LD 1. In patients with HFrEF with an unfavorable response to CRT with BiV pacing, continued efforts to optimize medical and device therapies are recommended to improve quality of life and long-term outcomes. 1 C-LD 2. In patients with an unfavorable response to CRT with BiV pacing, obtaining a posteroanterior and lateral chest X-ray is recommended to assess the LV lead position. 2a C-LD 3. In patients with an unfavorable response to CRT with BiV pacing and who have less than optimal LV pacing percentage, ablation or pharmacological suppression of frequent PVCs or better rhythm or rate control of AF is reasonable to improve cardiac function and patient symptoms. CPP Follow-up and Management

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