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Cardiac Physiologic Pacing for the Avoidance and Mitigation of Heart Failure

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37 Colors correspond to the Class of Recommendation on pages 46 and 47. Unfavorable response to CRT with BiV pacing Generator change Continue to optimize medical and device therapies (1, C-LD) Continue CRT with BiV pacing in patients with heart failure with improved ejection fraction (HFimpEF) at time of elective replacement (1, C-LD) Chest X-ray (posterior- anterior [PA], lateral) to assess LV lead position (1, C-LD) Continue CRT with BiV pacing in patients thought to have benefited from CRT at time of elective replacement (1, C-EO) LV pacing less than optimal: Ablation or pharmacological suppression of frequent premature ventricular contractions (PVCs) or better rhythm or rate control of AF (2a, C-LD) Shared decision-making: At the time of elective replacement, consider whether to replace cardiac resynchronization therapy-defibrillator (CRT-D) or revise to cardiac resynchronization therapy- pacemaker (CRT-P) (1, B-NR) Suboptimal response to CRT with BiV pacing Crossover to CSP with HBP or LBBAP (2a, C-LD) Crossover to surgical epicardial lead implantation (2a, B-NR) Shared decision-making: When high lead pacing threshold contributes to rapid battery drain, consider implantation of a new lead to reduce risks associated with frequent generator replacements (2b, C-EO) Time

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