7
Table 2. CRT Response Criteria
Response Criteria
Clinical response 1. Reduction in mortality
2. Reduction in HF hospitalizations
3. Improvement in NYHA class
4. Improvement in quality of life, symptoms, or clinical composite
scores
5. Increase in peak oxygen uptake (VO
2
) (eg, >10%)
6. Improvement in 6-minute walk distance (6MWD)
7. Reduction in HF medications, such as diuretic therapy (note:
continuation of guideline-directed medical therapy [GDMT]
is advised)
Echocardiographic
response
1. Improvement or stability in LVEF (eg, ≥5% absolute increase
or absence of worsening )
2. Reduction in LV size (eg, reduction in LV systolic or diastolic
dimensions or volume indices)
3. Increase in LV stroke volume
4. Reduction in mitral regurgitation
Detection of electrical dyssynchrony-induced cardiomyopathy
COR LOE Recommendations
1 B-NR 1. In patients who have substantial RVP that cannot be
minimized with programming, periodic assessment of
ventricular function is recommended to detect PICM.
2a B-NR 2. In patients with chronic LBBB, periodic assessment of
ventricular function is reasonable to detect cardiomyopathy.
Epidemiology, Pathophysiology, and Detection of
Electrical Dyssynchrony-induced Cardiomyopathy
