28
Treatment
Figure 17. Evaluation and Genetic Testing Protocol for
Patients With TAD
Patients With Thoracic Aortic Disease (TAD)
Features of MFS,
LDS, or vEDS
Family history of
TAD, intracranial
or peripheral
aneurysm
TAD <60 y of age
Positive result
Pathogenic or likely pathogenic
variant identified
Relative tests positive
Test offspring
Cascade testing for
at-risk relatives
Gene-based management
Relative tests negative
Offspring at general
population risk for TAAD
Genetic testing
—
+
+
