Treatment
Recommendation 1.4
➤ Multidisciplinary collaboration to formulate treatment and care
plans and disease management for patients with potentially
curable pancreatic cancer should be the standard of care. (Strong
Recommendation; EB-B-I)
Recommendation 1.5
➤ Every person with pancreatic cancer should be offered information
about clinical trials, including therapeutic trials in all lines of
treatment, as well as palliative care, biorepository/biomarker, and
observational studies. (Strong Recommendation; IC-B-I)
Recommendation 2.1
➤ Primary surgical resection of the primary tumor and regional lymph
nodes is recommended for patients with potentially curable pancreatic
cancer who meet all of the following criteria: no clinical evidence for
metastatic disease, a performance status and comorbidity profile
appropriate for a major abdominal operation, no radiographic interface
between primary tumor and mesenteric vasculature on high-definition
cross-sectional imaging, and a CA 19-9 level (in absence of jaundice)
suggestive of potentially curable disease. (Strong Recommendation;
EB-B-I)
Recommendation 3.1
➤ Preoperative therapy is recommended for patients with pancreatic
cancer who meet any of the following criteria: radiographic findings
suspicious but not diagnostic for extrapancreatic disease, a
performance status or comorbidity profile not currently appropriate
(but potentially reversible) for a major abdominal operation, a
radiographic interface between primary tumor and mesenteric
vasculature on cross-sectional imaging that does not meet
appropriate criteria for primary resection, or a CA 19-9 level (in
absence of jaundice) suggestive of disseminated disease. (Strong
Recommendation; EB-B-L)
Recommendation 3.2
➤ Preoperative therapy should be offered as an alternative treatment
strategy for any patient who meets all criteria in 2.1. (Strong
Recommendation; EB-B-L)
