10
Table 1. Drugs Used in the Management of Patients With
Multiple Myeloma
Agent Route Dose Schedule
Immunomodulatory drugs
alidomide Oral 50–200 mg Daily
Lenalidomide Oral 5–25 mg Daily for 21/28 days
Pomalidomide Oral 1–4 mg Daily for 21/28 days
Proteasome Inhibitors
Bortezomib Subcutaneous/
intravenous
0.7–1.6 mg/m
2
1–2× weekly
Carfilzomib Intravenous 20–70 mg/m
2
1–2× weekly for 3–4
weeks
Ixazomib Oral 2.3–4 mg Weekly for 3–4 weeks
Monoclonal antibodies
Daratumumab Intravenous 16 mg/kg Weekly → every 2 weeks →
monthly
Elotuzumab Intravenous 10 mg/kg Weekly → every 2 weeks
Alkylators
Cyclophosphamide Oral 50 mg–500 mg/m
2
Daily
Weekly
Melphalan Oral 9 mg/m
2
Daily × 4 days/cycle
Melphalan Intravenous 140–200 mg/m
2
Once for transplant
HDAC Inhibitors
Panobinostat Oral 10-20 mg 3× weekly
Steroids
Dexamethasone Oral 20–40 mg Weekly
Prednisone Oral 25–50 mg Every other day
Anthracyclines
Doxorubicin HCl
Liposomal
Intravenous 30 mg/m
2
Every 3 weeks
Treatment
