12
Treatment
Table 4. Comparison of Select Risk Prediction Models
Relevant To Older Adults With Multiple Myeloma
Factors
associated
with
increased
risk
International
Myeloma
Working Group
Revised-Myeloma
Comorbidity
Index
Geriatric Assessment
in Hematology Scale
Parameter pts Parameter pts Parameter pts
Age Age 76–80 1 60–69 1 –
Age >80 2 ≥70 2 –
Performance/
Functional
status
Any ADL
dependence
1 KPS 80–90 2 Gait speed ≤0.8m/s 1
Any IADL
dependence
1 KPS <70% 3 Any ADL
dependence
1
Comorbidities Charlson
Comorbidity
Index ≥ 2
1 Renal disease:
eGFR<60
1 Diabetes, BMI
>25kg/m
2
or
Cancer, lung
disease, heart
failure or smoking
a
1
Mod-severe
pulmonary
disease
1
Medications/
polypharmacy
– – ≥5 medications 1
Nutrition – – ≤8 on MNA-SF 1
Cognition – – ≥3 error on
SPMSQ
1
Psychosocial – – Felt depressed 3–7
days of past week
1
Other – Moderate/
severe frailty
phenotype
1 Self-reported
health fair or poor
1
Cytogenetics – Unfavorable 1 –
Total score Fit 0 Fit 0–3 Range 0–8
Intermediate
fit
1 Intermediate 4–6
Frail 2 Frail 7–9
a
See Wildes TM: American Society of Hematolog y Education Book, 2018 for full details on scoring
comorbidities.
