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Copyright © 2020 All rights reserved
ASCOMET07203a
Disclaimer
is pocket guide is derived om recommendations in the American Society of Clinical Oncology
Guideline. is resource is a practice tool based on ASCO
®
practice guidelines and is not intended
to substitute for the independent professional judgment of the treating physician. Practice guidelines
do not account for individual variation among patients. is pocket guide does not purport to
suggest any particular course of medical treatment. Use of the practice guidelines and this resource
are voluntary. e practice guidelines and additional information are available at www.asco.org/
gastrointestinal-cancer-guidelines. Copyright © 2020 by American Society of Clinical Oncology.
All rights reserved.
Abbreviations
ASCO, American Society of Clinical Oncolog y; CA 19-9, carbohydrate antigen 19-9;
dMMR, deficient mismatch repair; ECOG, Eastern Cooperative Oncolog y Group;
FOLFIRINOX, folinic acid (also called leucovorin, calcium folinate or FA), fluorouracil
(also called 5FU), irinotecan and oxaliplatin; FU, fluorouracil; LV, leucovorin; MSI-H, high
levels of microsatellite instability; NAB, nanoparticle albumin-bound; NTRK, neurotrophin
tyrosine receptor kinase; OFF, leucovorin, 5-fluorouracil and oxaliplatin; PARP, Poly (ADP-
ribose) polymerase; PCO, provisional clinical opinion; PS, performance status; TRK, tyrosine
kinase
Source
Sohal DPSS, et al. Metastatic Pancreatic Cancer: ASCO Guideline Update. J Clin Oncol. 2020
August 5 DOI: 10.1200/JCO.20.01364
Sohal DPSS, et al. J Clin Oncol. 2018 May 23. DOI: 10.1200/JCO.2018.78.9636
Recommendation Grading
Type Benefit/harm Evidence Quality
Strength of
Recommendation
EB Evidence-
based
B Benefits
outweigh
harms
H High Strong
CB
Consensus-
based
H Harms
outweigh
benefits
I Intermediate Moderate
IC Informal
consensus
B/H Relative
balance of
benefits and
harms
L Low Weak
Ins Insufficient
ASCO believes that cancer clinical trials are vital to inform medical decisions and
improve cancer care and that all patients should have the opportunity to participate.
Additional information, which may include data supplements, slide sets, and other clinical
tools and resources, is available at www.asco.org/gastrointestinal-cancer-guidelines.
