ASCO GUIDELINES Bundle

Medication-Related Osteonecrosis of the Jaw

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9 Table 4. MASCC/ISOO Daily Oral Care Plan for Patients Intervention Basic Oral Care Plan Moisturizing the Oral Cavity • Moisturize the mouth with water or artificial saliva products or other water-soluble lubricants for use inside the mouth. • Avoid glycerin or lemon-glycerin swabs since they dry the mouth and do not moisturize. • Apply lubricant after each cleaning, at bedtime, and as needed. • Water-based lubricant needs to be applied more frequently. • Frequent rinsing as needed with basic mouth rinse. Lip Care • To keep lips lubricated and moisturized, use only animal or plant-based oils such as bees wax, cocoa butter, and lanolin. Avoid petroleum-based products as these will cause drying and cracking. You should be having follow-ups a minimum of every 6 months with your Dentist. If you notice any signs or symptoms, please advise either your Dentist or Oncologist. Table 5. Treatment Strategies by Stage of MRONJ a Staging of MRONJ b Treatment Strategies c At risk: No apparent necrotic bone in patients who have been treated with oral or intravenous BMAs • No treatment indicated • Patient education and reduction of modifiable risk factors Increased Risk: No clinical evidence of necrotic bone but nonspecific clinical findings, radiographic changes, and symptoms • Symptomatic management, including use of pain medication and close scrutiny and follow-up. • Refer to dental specialist and follow-up every 8 weeks with communication of lesion status to oncologist • Patient education and reduction of modifiable risk factors Stage 1: Exposed and necrotic bone or fistulas that probes to bone in patients who are asymptomatic and have no evidence of infection • Antibacterial mouth rinse • Clinical follow-up on a q8week basis by dental specialist with communication of lesion status to oncologist • Patient education and reduction of modifiable risk factors (cont'd)

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