ASCO GUIDELINES Bundle

Management of Metastatic Clear Cell Renal Cell Carcinoma

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106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies at GuidelineCentral.com Copyright © 2022 All rights reserved ASCORCC04222a ASCO believes that cancer clinical trials are vital to inform medical decisions and improve cancer care and that all patients should have the opportunity to participate. Additional information, which may include data supplements, slide sets, and other clinical tools and resources, is available at www.asco.org/genitourinary-cancer-guidelines. Disclaimer is pocket guide is derived om recommendations in the American Society of Clinical Oncolog y Guideline. is resource is a practice tool based on ASCO ® practice guidelines and is not intended to substitute for the independent professional judgment of the treating physician. Practice guidelines do not account for individual variation among patients. is pocket guide does not purport to suggest any particular course of medical treatment. Use of the practice guidelines and this resource are voluntary. e practice guidelines and additional information are available at www.asco.org/ genitourinary-cancer-guidelines. Copyright © 2022 by American Society of Clinical Oncolog y. All rights reserved. Source Rathmell WK, Rumble RB, Van Veldhuizen PJ, et al. Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline. J Clin Oncol. 2022 June 21. doi:10.1200/JCO.22.00868. Abbreviations CAIX, carbonic anhydrase IX; ccRCC, clear cell renal cell carcinoma; HD-IL2, high dose interleukin-2; IMDC, International Metastatic RCC Database Consortium; PAX8, paired box gene 8; RANKL, receptor activator of nuclear factor kappa-Β ligand; RECIST, response evaluation criteria in solid tumors; TKI, tyrosine kinase inhibitor; VEGFR, vascular endothelial growth factor receptor

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