10
Treatment
Table A2: Immunosuppressive Agents
Immunosuppressive
Agents Dosing Indications
Nonbiological immunosuppressive agents
Azathioprine (AZA)
(non-selective
immunosuppressant)
50 mg/day with subsequent
incremental increase by 25–50 mg
every 1–2 weeks up to 2 mg/kg/day
Steroid-refractory
immune-related
hepatitis, myositis,
nephritis
Cyclophosphamide
(CYC)
(non-selective
immunosuppressant)
1–2 mg/kg/day Steroid-refractory
pneumonitis,
nephritis,
hematological irAEs
Cyclosporine
(Calcineurin
inhibitors [CNIs])
1–2 mg/kg/day Hematological
irAEs, SCAR, and
nephritis
Eltrombopag
(non-selective
immunosuppressant)
Starting dose of 50 mg daily Refractory aplastic
anemia
Etoposide
(topoisomerase II
inhibitor)
150 mg/m2 IV, twice weekly for weeks
1-2, then once weekly
Severe or refractory
HLH
Hydroxychloroquine
(non-selective
immunosuppressant)
200 to 400 mg daily administered
as a single dose or in two divided
doses, but no more than 5 mg/kg/day
calculated based upon actual body
weight
Mild or moderate
inflammatory
arthritis
(cont'd)