Disclaimer
is pocket guide is derived om recommendations in the American Society of Clinical Oncology
Guideline. is resource is a practice tool based on ASCO
®
practice guidelines and is not intended to
substitute for the independent professional judgment of the treating physician. Practice guidelines do
not account for individual variation among patients. is pocket guide does not purport to suggest any
particular course of medical treatment. Use of the practice guidelines and this resource are voluntary.
e practice guidelines and additional information are available at www.asco.org/breast-cancer-
guidelines. Copyright © 2018 by American Society of Clinical Oncology. All rights reserved.
Source
Burstein HJ, Lacchetti C, Anderson H, Buchholz TA, Davidson NE, Gelmon KA, Giordano SH,
Hudis CA, Solky AJ, Stearns V, Winer EP, Griggs JJ. Adjuvant Endocrine erapy for Women With
Hormone Receptor-Positive Breast Cancer: ASCO Clinical Practice Guideline Focused Update.
J Clin Oncol. 2018 Nov 19:JCO1801160. doi: 10.1200/JCO.18.01160. [Epub ahead of print]
ASCO believes that cancer clinical trials are vital to inform medical decisions and
improve cancer care and that all patients should have the opportunity to participate.
Additional information, which may include data supplements, slide sets, and other clinical tools
and resources, is available at www.asco.org/breast-cancer-guidelines
Abbreviations
AI, aromatase inhibitor; ASCO, American Society of Clinical Oncology ;ER, estrogen receptor;
PAM, prediction analysis of microarray; ROR, risk of recurrence; mg, milligram; PO, by mouth;
qd, every day; GnRH, Gonadotropin-releasing hormone
Recommendation Grading
Type Benefit/harm Evidence Quality
Strength of
Recommendation
EB Evidence-
based
B Benefits
outweigh harms
H High Strong
FC
Formal
consensus
H Harms outweigh
benefits
I Intermediate Moderate
IC Informal
consensus
B/H Relative balance
of benefits and
harms
L Low Weak
Ins Insufficient
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