11
Table 2. Clinical Stage + Pathologic Stage + ER status +
Nuclear grade (CPS&EG score)
Calculation instructions: Add the points for Clinical Stage +
Pathologic Stage + ER status + Nuclear grade to derive a sum
(CPS&EG score) between 0 and 6.
Stage/feature Points
Clinical Stage
(AJCC staging
1
)
I 0
IIA 0
IIB 1
IIIA 1
IIIB 2
IIIC 2
Pathologic Stage
(AJCC staging
1
)
0 0
I 0
IIA 1
IIB 1
IIIA 1
IIIB 1
IIIC 2
Receptor status
ER negative
2
1
Nuclear grade
3
Nuclear grade
3
1
1
AJCC: American Joint Committee on Cancer (https://cancerstaging.org/Pages/default.aspx)
2
ER: Estrogen receptor; definitions for ER negativity see eligibility criteria section 4.1.4.a
3
In the unlikely situation nuclear grade cannot be determined, regular histologic grade should be
used; if only Nottingham overall grade is reported, the Nottingham overall grade must be 9 to be
scored as 1 point in the CPS&EG score (http://patholog y.jhu.edu/breast/grade.php).
From e New England Journal of Medicine, Tutt ANJ et al, Adjuvant Olaparib for Patients with
BRCA1- or BRCA2-Mutated Breast Cancer, 384, 2394-2405. Copyright ©2021 Massachusetts
Medical Society. Reprinted with permission from Massachusetts Medical Society.
