Key Points
➤ Chemotherapy-induced neuropathy (CIPN) is a serious clinical problem
caused by a substantial number of cytotoxic drugs, including taxanes,
platinums, vinca alkaloids, epothilones, eribulin, and bortezomib.
➤ No agents are recommended for the prevention of CIPN.
• Duloxetine is the only agent that has appropriate evidence to support its use, but the
amount of benefit from duloxetine is limited.
➤ Therefore, prevention and minimizing risk are the primary objectives.
➤ Because patients with CIPN can have balance troubles and a higher
chance of falling, it is reasonable to consider physical and/or occupational
therapy approaches for patients with such CIPN-related disabilities.
