ASCO GUIDELINES Bundle

Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy

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9 Study Population Administration Characteristics Considerations Patients aged 65+ with a solid tumor malignancy or lymphoma starting a new chemotherapy regimen (any-line) PRO/Administered; 5 min Available online at: http://www.mycarg. org/Chemo_Toxicity_ Calculator Can ask GA variables as part of history or include as part of PRO assessment Patients aged 70+ years with histologically proven cancer who were starting chemotherapy PRO/Administered; Estimated time to completion is on par with full GA (20-30 minutes) Available online: https://moffitt.org/ for-healthcare-providers/ clinical-programs-and- services/senior-adult- oncolog y-program/ senior-adult-oncolog y- program-tools e CRASH Scale includes GA measures known also to predict other adverse outcomes such as mortality, functional decline, and hospitalizations: IADLs, MMSE, and MNA. Study Population and Evidence Administration characteristics Considerations Several large studies have been conducted that include patients aged 70+, which included patients with both solid and hematologic malignancies starting a new chemotherapy agent. G8 is independently associated with mortality (1 year and 3 years) even when controlling for ECOG PS and stage of cancer. Administered; 5-10 min G8 can also be used as a screening tool to identify older patients who need more comprehensive GA.

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