Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer
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2nd line trastuzumab
deruxtecan
If not prior trastuzumab
deruxtecan, then 3rd line
trastuzumab deruxtecan
Tucatinib + trastuzumab +
capecitibine
OR
Trastuzumab deruxtecan
OR
Neratinib + capecitabine
OR
Lapatinib combinations
OR
Trastuzumab combinations
OR
Margetuximab + chemotherapy
OR
Petruzumab
OR
Abemaciclib + trastuzumab +
fulvestrant, if HR+
Further
progression?
YES
Monitor
Options
include
a
Except if contraindications to taxanes.
