46
Treatment
Figure 13. Diagnostic and Treatment of Transthyretin Cardiac
Amyloidosis Algorithm
Hematology-oncology
consultation and
consider heart or
other biopsy
Cardiac amyloidosis
unlikely
AL-CM
Amyloid on heart
biopsy?
Treatment by
hematologist-
oncologist
HFrEF
Individualize therapy
(see text)
No evidence
of amyloid
Evidence of
amyloid
• Referral to genetic counselor
• Potential screening of family
members
• TTR silencer therapy if
neuropathy
ATTR-CM
