12
Assessment
4.3. Genetic Evaluation and Testing
COR LOE
Recommendations
1 B-NR 1. In first-degree relatives of selected patients with genetic or
inherited cardiomyopathies, genetic screening and counseling
are recommended to detect cardiac disease and prompt
consideration of treatments to decrease HF progression and
sudden death.
2a B-NR 2. In select patients with nonischemic cardiomyopathy, referral
for genetic counseling and testing is reasonable to identify
conditions that could guide treatment for patients and family
members.
Table 6. Selected Potential Causes of Elevated Natriuretic
Peptide Levels
Cardiac
• HF, including RV HF syndromes
• ACS
• Heart muscle disease, including LVH
• VHD
• Pericardial disease
• AF
• Myocarditis
• Cardiac surgery
• Cardioversion
• Toxic-metabolic myocardial insults,
including cancer chemotherapy
Noncardiac
• Advancing age
• Anemia
• Renal failure
• Pulmonary: Obstructive sleep apnea,
severe pneumonia
• Pulmonary embolism, pulmonary
arterial hypertension
• Critical illness
• Bacterial sepsis
• Severe burns
