Table 1. Summary of Recommended Interventions in Adult
Populations
Intervention
Strength of
Recommendation
Critical Outcomes Showing Clinically
Significant Improvement*
Excessive
Daytime
Sleepiness Cataplexy
Disease
Severity
Quality
of Life
Narcolepsy
Modafinil Strong
✓ ✓ ✓
Pitolisant Strong
✓ ✓ ✓
Sodium Oxybate Strong
✓ ✓ ✓
Solriamfetol Strong
✓ ✓ ✓
Armodafinil Conditional
✓ ✓
Dextroamphetamine Conditional
✓ ✓
Methylphenidate Conditional
✓
✓ Critical outcomes showing clinically significant improvement.
*
Accident risk and work/school performance/attendance were critical outcomes.
However, no data were available.
