F ASH
card
™
Adult Patients With Narcolepsy
Summary of Recommended Interventions in Adult Populations
Intervention
Strength of
Recommendation
Critical Outcomes Showing Clinically
Significant Improvement*
Excessive
Daytime
Sleepiness Cataplexy
Disease
Severity
Quality of
Life
Narcolepsy
Modafinil Strong
✓ ✓ ✓
Pitolisant Strong
✓ ✓ ✓
Sodium Oxybate Strong
✓ ✓ ✓
Solriamfetol Strong
✓ ✓ ✓
Armodafinil Conditional
✓ ✓
Dextroamphetamine Conditional
✓ ✓
Methylphenidate Conditional
✓
✓ Critical outcomes showing clinically significant improvement.
*
Accident risk and work/school performance/attendance were critical outcomes.
However, no data were available.
Republished with permission of American Academy of Sleep Medicine (AASM), from the Journal of Clinical
Sleep Medicine, the official journal of AASM. Maski K, Trotti LM, Kotagal S, Robert Auger R, Rowley JA,
Hashmi SD, Watson NF. Treatment of central disorders of hypersomnolence: an American Academy of Sleep
Medicine clinical practice guideline. J Clin Sleep Med. 2021 Sep 1;17(9):1881-1893
Disclaimer
is FLASHcard™ attempts to define principles of practice that should produce high-quality
patient care. It focuses on the needs of primary care practice but also is applicable to providers at all levels.
is FLASHcard™ should not be considered exclusive of other methods of care reasonably directed at obtaining
the same results. e ultimate judgment concerning the propriety of any course of conduct must be made by the
clinician aer consideration of each individual patient situation. Neither IGC, the medical associations, nor
the authors endorse any product or service associated with the distributor of this clinical reference tool.
AASMNAR09212d
The distribution of this educational resource was supported by Avadel
CNS Pharmaceuticals, LLC. Avadel was not involved in the development
of the underlying guidelines on which this pocket guide is based.
To access this pocket guide online,
visit GuidelineCentral.com/Narcolepsy
PM-US-SXB-0354
