19
Definitive intention radiation (IMRT) +/–
Chemotherapy (taxane monotherapy or
with platin or anthracycline)
Palliative
Chemotherapy
and/or Radiation
Best Supportive
Care/Hospice
Surgery
(if feasible)
N
Y
Targeted therapy
(e.g., fusions, ALK: crizotinib,
ceritinib, alectinib;
RET: pralsetinib, selpercatinib;
NTRK: larotrectinib, entrectinib)
1
or
or
Excellent tumor
response?
1
Additional agents exist and are in development, listing not meant to be comprehensive; clinical
trials preferred if available; see text.
