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Anaplastic Thyroid Cancer ATA 2021

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13 Recommendation 11 ➤ At all stages of palliative care and hospice care in ATC patients, practitioners should be aware of family systems, and how they affect patient decision-making. (S-L) Surgical Management of ATC Recommendation 12 ➤ For patients with confined (stage IVA/IVB) ATC in whom R0/R1 resection is anticipated, we strongly recommend surgical resection. (S-L) • Value Statement: The authors for this recommendation placed a higher value for the benefit (longer overall survival) of surgical resection and placed a lower value for potential morbidity and subsequent delay in chemotherapy and/or radiation therapy. Recommendation 13 ➤ Radical resection (including laryngectomy, tracheal resections, esophageal resections, and/or major vascular or mediastinal resections) is generally not recommended given the poor prognosis of ATC and should be considered only very selectively after thorough discussion by the multidisciplinary team, also considered in light of new information based upon mutations present and the availability of targeted therapies. (S-L) Good Practice Statement 6 ➤ If surgery is undertaken, intraoperative frozen section and pathology consultation may be a helpful adjunct to inform surgical decision- making. (GPS) Good Practice Statement 7 ➤ In patients without impending airway compromise, we advise against preemptive tracheostomy placement. (GPS)

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