➤ In patients with asthma in whom treatment is being considered,
we suggest the use of FeNO in addition to usual care over usual care
alone (conditional recommendation, low confidence in estimates of
effect).
Figure 1. FeNO Treatment for Individuals With Asthma
Exacerbations High
Asthma Control Low
• Investigate further
• Address confounders
• Additional factors
• Step up therapy
• Favor type 2 treatment
• Clinical judgement
Exacerbations Low
Asthma Controlled
• Clinical judgement
• Adjust management
• Step down therapy
• Clinical judgement
• Consider step down
• Unable to use FeNO to
titrate therapy
FeNO ppb
LOW HIGH
Conceptual framework for the use of FeNO to guide treament decitions for individuals
with asthma. e decision to act upon an individual FeNO value in an individual
patient requires that the clinician combine clinical judgement based on the preceived
probability of benefit with particular attention to the key outcome measures such as
exacerbation risks that were assessed in the full text guideline.
Treatment
