Key Points
Antihyperglycemic Therapy
Glycemic Targets
ÎÎHbA1c < 7.0% (mean plasma glucose ~150-160 mg/dL
[~8.3-8.9 mmol/L])
ÎÎFasting and premeal glucose < 130 mg/dL (< 7.2 mmol/L)
ÎÎPostprandial glucose < 180 mg/dL (< 10.0 mmol/L)
ÎÎIndividualization is key:
• More stringent targets (HbA1c 6.0-6.5%) – patients with short disease duration,
long life expectancy, no significant cardiovascular disease
• Less stringent targets (HbA1c 7.5-8.0%+) – patients with history of severe
hypoglycemia, limited life expectancy, advanced complications, extensive
comorbid conditions
ÎÎAvoidance of hypoglycemia
Figure 4. Approach to Management of Hyperglycemia
Reprinted with permission from: Inzucchi SE, et al. Diabetes Care. 2012 Jun;35(6):1364-1379.
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