Advantages
Disadvantages
Cost
• No hypoglycemia
• ? ↓ CVD events
(Cycloset Safety Trial)
• Generally modest HbA1c efficacy
• Dizziness/syncope
• Nausea
• Fatigue
• Rhinitis
High
• No hypoglycemia
• Weight reduction
• ? Potential for improved
β-cell mass/function
• ? Cardiovascular
protective actions
• Gastrointestinal side effects (nausea/
vomiting)
• ? Acute pancreatitis
• C-cell hyperplasia/medullary thyroid
tumors in animals
• Injectable
• Training requirements
High
• ↓ Postprandial glucose
excursions
• Weight reduction
• Generally modest HbA1c efficacy
• Gastrointestinal side effects (nausea/
vomiting)
• Hypoglycemia unless insulin dose is
simultaneously reduced
• Injectable
• Frequent dosing schedule
• Hypoglycemia
• Weight gain
• ? Mitogenic effects
• Injectable
• Training requirements
• "Stigma" (for patients)
High
• Universally effective
• Theoretically unlimited
efficacy
• ↓ Microvascular risk
(UKPDS)
Variablee
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