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2021 Chest Pain Guidelines

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45 Continue preventive therapies (1) Optimize preventive therapies (1) Optimize preventive therapies (1) Persistent symptoms? Moderate–severe ischemia Mild ischemia Inconclusive CAC (2a) CCTA (2a) Invasive coronary angiography (1) YES Invasive coronary angiography (1) NO High-risk CAD † or frequent angina Test choice should be guided by local availability and expertise. * Test choice guided by patient's exercise capacity, resting electrocardiographic abnormalities; CCTA preferable in those <65 years of age and not on optimal preventive therapies; stress testing favored in those ≥65 years of age (with a higher likelihood of ischemia). † High-risk CAD means le main stenosis ≥ 50%; anatomically significant 3-vessel disease (≥70% stenosis).

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