31
Table 6. Effect of Protease Inhibitors and Nonnucleoside
Reverse Transcriptase Inhibitors (NNRTIs) on
Statins
Statin Protease Inhibitors NNRTI
Rosuvastatin Acceptable with appropriate
dosing and monitoring. Lopinavir/
ritonavir and tipranavir + ritonavir
increase rosuvastatin's AUC. May
need to start rosuvastatin at lower
dose with lopinavir/ritonavir. No
dose adjustments with cobicistat.
Cobicistat increases C
max
89% and
AUC by 38%.
Acceptable with
appropriate dosing and
monitoring. No data on
doravirine.
Simvastatin Contraindicated (greatly increase
simvastatin's AUC)
Acceptable with
appropriate dosing and
monitoring. Efavirenz
and etravirine decrease
simvastatin's AUC. No data
for nevirapine, doravirine.
May need higher
simvastatin starting dose.
(cont'd)
