10
Treatment
Table 7. DMARDs
Drug Mechanism Type
Abatacept T-cell costimulatory signal inhibitor bDMARD
Adalimumab TNF inhibitor bDMARD
Baricitinib JAK1 and JAK2 inhibitor tsDMARD
Certolizumab pegol TNF inhibitor bDMARD
Etanercept Decoy TNF receptor bDMARD
Golimumab TNF inhibitor bDMARD
Hydroxychloroquine
(anti-malarial)
TNF-alpha, induce apoptosis of inflammatory
cells and decrease chemotaxis
csDMARD
Infliximab TNF inhibitor bDMARD
Leflunomide Pyrimidine synthesis inhibitor csDMARD
Methotrexate (MTX) Purine metabolism inhibitor csDMARD
Rituximab Chimeric monoclonal antibody against CD20
on B-cell surface
bDMARD
Sarilumab IL-6 receptor antagonist bDMARD
Sulfasalazine (SSZ) Suppression of IL-1 & TNF-alpha, induce
apoptosis of inflammatory cells and increase
chemotactic factors
csDMARD
Tocilizumab IL-6 receptor antagonist bDMARD
Tofacitinib JAK1 and JAK3 inhibitor tsDMARD
Upadacitinib JAK1 inhibitor bDMARD
