11
Some Drug Interactions Contraindications
• During or within 14 days following
monoamine oxidase (MAO)
inhibitors, sympathomimetics,
alcohol, adrenergic neuron
blocking drugs, and possibly
some anesthetic agents
• History of cardiovascular
disease (e.g., coronary artery
disease, stroke, arrhythmias,
congestive heart failure,
uncontrolled hypertension)
• During or within 14 days
following the administration of
monoamine oxidase inhibitors
• Hyperthyroidism
• Glaucoma
• Agitated states
• History of drug abuse
• Pregnancy (see Precautions)
• Nursing (see Precautions)
• Known hypersensitivity
or idiosyncrasy to the
sympathomimetic amines
• May alter the exposure to oral
contraceptives, causing irregular
menstrual bleeding but not an
increased risk of pregnancy
• Oral contraceptives should not be
discontinued if spotting occurs.
• May potentiate central nervous
system depressants such as
alcohol Patients should avoid
concomitant alcohol.
• May potentiate hypokalemia of
non-potassium-sparing diuretics
• Phentermine is contraindicated
during or within 14 days following
the administration of monoamine
oxidase inhibitors because of the
risk of hypertensive crisis.
• Age <12 years
• Pregnancy
• Glaucoma
• Uncontrolled hyperthyroidism
• During or within 14 days of
taking monoamine oxidase
inhibitors
• Hypersensitivity or idiosyncrasy
to sympathomimetic amines
• History of cardiovascular
disease (e.g., coronary artery
disease, stroke, arrhythmias,
congestive heart failure,
uncontrolled hypertension)
• During or within 14 days
following the administration of
monoamine oxidase inhibitors