19
Some Drug Interactions Contraindications
Low potential for pharmacokinetic
drug-drug interactions
• Obesity due to suspected
proopiomelanocortin (POMC),
proprotein convertase
subtilisin/kexin type 1 (PCSK1),
or leptin receptor (LEPR)
-def iciency with POMC, PCSK1,
or LEPR variants classif ied as
benign or likely benign.
• Other types of obesity not
related to POMC, PCSK1 or
LEPR def iciency, or BBS,
including obesity associated
with other genetic syndromes
and general (polygenic)
obesity.
• Risk of anti-metreleptin
antibodies with neutralizing
activity and risk of lymphoma
• Cytochrome p450 enzymes
• Hypersensitivity
• General obesity not associated
with congenital leptin
def iciency
Suicidal thoughts and behaviors The use of phentermine along
with serotonergic agents such
as selective serotonin reuptake
inhibitors (e.g., fluoxetine,
sertraline, fluvoxamine,
paroxetine) can cause serotonin
syndrome.
