18
Anti-obesity Pharmacotherapy
Eating Disorders and Miscellaneous
Agent/Dose Description
Main Side Effects/
Adverse Reactions
Setmelanotide
(IMCIVREE™)
Dose:
Age ≥6 years:
1–3mg subcut QD
Melanocortin-4
receptor agonist
Injection site reactions,
skin hyperpigmentation,
nausea, headache,
diarrhea, abdominal
pain, back pain, fatigue,
vomiting, depression,
upper respiratory
tract infection, and
spontaneous penile
erection.
Metreleptin
Subcutaneous
Injection
(Myalept
®
)
Starting Dose:
2.5 mg (men), 5 mg
(women) subcut QD
Max: 10 mg QD
Leptin analog
indicated for
congenital or
acquired generalized
lipodystrophy
Headache,
hypoglycemia,
decreased weight,
abdominal pain
Fluoxetine
Indication:
Bulimia nervosa
Dose: 60 mg QD
Serotonin re-uptake
inhibitors
Abnormal dreams,
abnormal ejaculation,
anorexia, anxiety,
asthenia, diarrhea,
dry mouth, dyspepsia,
flu syndrome,
impotence, insomnia,
decreased libido,
nausea, nervousness,
pharyngitis, rash,
sinusitis, somnolence,
sweating, tremor,
vasodilatation, and
yawning
