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Figure 5. Photomicrographs of Surgical Lung Biopsy
Specimens from Two Different Sites in a Patient
with Fibrotic Hypersensitivity Pneumonitis
(A) Scanning magnification view showing multiple sections of a right-lower-lobe biopsy
specimen. ere is patchy fibrosis with architectural distortion, a combination of findings
that resembles usual interstitial pneumonia. Magnification, 6×. (B) Low-magnification
photomicrograph showing one of the sections illustrated in A, characterized by a pattern
of patchy fibrosis with subpleural honeycomb change that resembles usual interstitial
pneumonia. Magnification, 17×. (C) Higher-magnification view showing expansion of
the peribronchiolar interstitium by a cellular infiltrate of mononuclear inflammatory cells
(upper le) and isolated Schaumann bodies (arrows) at the edge of the biopsy specimen.
Magnification, 46×. (D) High-magnification photomicrograph showing one of the isolated
Schaumann bodies illustrated in C. Magnification, 400×. (E) Photomicrograph from
another section illustrated in A showing an isolated Schaumann body (arrow) in the fibrotic
peribronchiolar interstitium. Magnification, 63×. (F) Low-magnification photomicrograph
of a right-middle-lobe biopsy specimen from the same patient showing features more closely
resembling nonfibrotic hypersensitivity pneumonitis. ere is a more cellular chronic
interstitial pneumonia accentuated around bronchioles with scattered calcified Schaumann
bodies (arrows) marking isolated multinucleated giant cells. Magnification, 43×. Hematoxylin
and eosin staining was used.
