AAN GUIDELINES Bundle

Classification of Management Recommendations Classification Definition Strong (A) Established as effective, ineffective, or harmful (or established as useful/predictive or not useful/predictive) for the given condition in the specified population. (Level A rating requires at least two consistent Class I studies.)* Moderate (B) Probably effective, ineffective, or harmful (or probably useful/ predictive or not useful/predictive) for the given condition in the specified population. (Level B rating requires at least one Class I study or two consistent Class II studies.) Weak (C) Possibly effective, ineffective, or harmful (or possibly useful/ predictive or not useful/predictive) for the given condition in the specified population. (Level C rating requires at least one Class II study or two consistent Class III studies.) Insufficient (U) Data inadequate or conflicting; given current knowledge, treatment (test, predictor) is unproven. Note: In exceptional cases, one convincing Class I study may suffice for an "A" recommendation if 1) all criteria are met, 2) the magnitude of effect is large (relative rate improved outcome is greater than 5 and the lower limit of the confidence interval is greater than 2). Source Cortese I, Chaudhry V, So YT, Cantor F, Cornblath DR, Rae-Grant A. Evidence-Based Guideline Update: Plasmapheresis in Neurologic Disorders. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology® 2011;76:294–300. Endorsed by the American Association of Neuromuscular and Electrodiagnostic Medicine. The National Multiple Sclerosis Society endorsed only the section that relates to the use of plasma exchange for multiple sclerosis. Disclaimer See published guidelines for complete text and AAN Disclosure statement. The views expressed here are those of the authors and do not represent those of the National Institutes of Health or any other part of the US Government. No official support or endorsement by the National Institutes of Health is intended or should be inferred. This Guideline attempts to define principles of practice that should produce high-quality patient care. It focuses on the needs of primary care practice, but also is applicable to providers at all levels. This Guideline should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool. 5740 Executive Drive  Suite 218 Baltimore, MD 21228  TEL: 410-869-3332  •  FAX: 410-744-2150  For additional copies: orders@GuidelineCentral.com Copyright © 2011 All rights reserved 3

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