16
Treatment
Antipsychotic medications: relative side effects of
oral formulations
Generic name Akathisia Parkinsonism Dystonia
First-generation antipsychotics
Chlorpromazine ++ ++ ++
Fluphenazine +++ +++ +++
Haloperidol +++ +++ +++
Loxapine ++ ++ ++
Molindone ++ ++ ++
Perphenazine ++ ++ ++
Pimozide +++ +++ ++
Thioridazine + + +
Thiothixene +++ +++ +++
Trifluoperazine ++ ++ ++
Second-generation antipsychotics
Aripiprazole ++ + +
Asenapine ++ + ++
Brexpiprazole ++ + +
Cariprazine ++ + +
Clozapine + + +
Iloperidone + + +
Lurasidone ++ ++ ++
Olanzapine ++ ++ +
Paliperidone ++ ++ ++
Quetiapine + + +
Risperidone ++ ++ ++
Ziprasidone ++ + +
