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Key Points ➤ All patients who use tobacco should receive treatment for their dependence, rather than simply being encouraged to stop. ➤ The goal is to improve patient-centered care of tobacco dependence by identifying a single evidence-based pathway that balances important outcomes, including short- and long- term tobacco abstinence and serious adverse events (SAEs), while accounting for important clinical variability. ➤ The panel recognized that the epidemic of tobacco dependence involves an array of social, environmental, and behavioral determinants. However, the panel had to omit important topics, such as communication and counseling methods, healthcare system designs, epidemic-control policies, and second-line therapy, because each is sufficiently robust to warrant its own guideline. ➤ This guideline was created with the assumption that accepted foundations of tobacco-dependence treatment are already in practice (Box 1).

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