8
Treatment
Table 3. Dosing Guidelines for Drugs Used in the
Management of NTM Pulmonary Disease
Drug Daily Dosing
Thrice
Weekly
Dosing
Hepatic
Impairment
Renal
Impairment
Oral
Azithromycin 250–500 mg
per day
500 mg per day N/A N/A
Ciprofloxacin 500–750 mg
twice per day
N/A N/A 250–500
mg dosed
at intervals
according to
CrCl
Clarithromycin 500 mg twice
per day
500 mg twice
per day
N/A Reduce dose
by 50% if CrCl
<30 mL/min
Clofazimine
a
100–200 mg
per day
N/A Caution in
severe hepatic
impairment
N/A
Doxycycline 100 mg once to
twice a day
N/A N/A N/A
Ethambutol 15 mg/kg per
day
25 mg/kg per
day
N/A Increase dosing
interval (eg,
15–25 mg/kg,
3 times per week)
Isoniazid 5 mg/kg up to
300 mg per day
N/A Caution N/A
Linezolid 600 mg once or
twice per day
b
N/A N/A N/A
Moxifloxacin 400 mg per day N/A N/A N/A
Rifabutin 150–300 mg
per day
(150 mg per
day with
clarithromycin)
300 mg per day Caution Reduce dose
by 50% if CrCl
<30 mL/min
Rifampicin
(rifampin)
10 mg/kg
(450 mg or
600 mg ) per day
600 mg per day Caution N/A
Trimethoprim/
sulfamethoxazole
800 mg/160 mg
tab twice daily
N/A Caution Reduce dose
by 50% if CrCl
5–30 mL/min
