ATS GUIDELINES Bundle

Sarcoidosis

American Thoracic Society Quick-Reference GUIDELINES Apps

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9 Testing and Clinical Pearls Culture is diagnostic gold standard; IFN-γ release assay used for screening, and preferable to tuberculin skin testing due to anerg y Culture is the gold standard Culture Serum agglutination and ELISA; livestock exposure history Periodic acid–Schiff stain; immunohistochemistry testing ; diarrhea, weight loss, and joint pains Culture is the gold standard, but can be difficult; histolog y; PCR Serologic assay, then repeat in 2 wk; rabbit exposure Titers >1:256; cat exposure Serolog y; PCR; livestock exposure Culture; Aspergillus IgG; histolog y Culture; urine histoplasma antigen Culture; histolog y; blasto Ag is nonspecific Serologic tests using EIA for IgM and IgG; then confirmatory immunodiffusion Cryptococcal serum antigen Histolog y; screen with β-D-glucan assay Granulomas may occasionally be found Toxoplasma serologic assay IgM and IgG Serolog y and microscopic visualization of eggs in stool or urine

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