11
Histolog y and PCR for Leishmania
EIA; ultrasound imaging
Pinworm paddle test, then microscopy
Histolog y; eosinophilia
Clonal cell population; rarely can have elevated serum ACE
PET useful for selecting biopsy site but not diagnostic; biopsy must be performed to
diagnose
Atypical clonal EBV-positive B cells; multiple pulmonary nodules with lymphocytic
transmural angiitis and granulomas noted sometimes in skin
Serum α fetoprotein, human chorionic gonadotropin, lactate dehydrogenase
MPO or PR3 ANCA+, renal disease, necrotizing vasculitis; eosinophilic infiltration if
EGPA
Nonnecrotizing granulomas, LIP, and follicular bronchiolitis on lung biopsy;
hypogammaglobulinemia and recurrent infections
Multiple subpleural nodules in patient with anti-CCP antibodies, arthralgias;
necrotizing granulomas
Young smoker; multiple bizarre-shaped upper lung zone cysts and/or nodules;
Langerhans cell stain CD1a and S100 positive; eosinophilic granulomas most common
Elevated serum IgG4; elevated tissue IgG4+ plasma cell count and IgG4:IgG ratio;
granulomas rare; differential diagnosis with multicentric Castleman disease
GI symptoms; granulomatous bronchiolitis
Cholestasis; antimitochondrial antibodies; portal based, poorly formed granulomas
with bile duct destruction
Cholestasis; P-ANCA
+
; ulcerative colitis associated; biliary strictures present,
granulomas rare and not associated with bile duct destruction
Abnormal liver function tests and autoantibodies (e.g., anti–smooth muscle); syncytial
multinucleated giant cells are rare in adults but may be observed in children or
adolescents
