18
Diagnosis
Clinical presentation
e figure outlines a general approach to the diagnosis of sarcoidosis and refers to tables presented with
this article.
Highly supportive of sarcoidosis:
• Löfgren's syndrome
• Lupus pernio
• Heerfordt's syndrome
• Bilateral hilar adenopathy (BHA),
no symptoms
Clinical
presentation
supportive of
sarcoidosis
Figure 3. Schematic of recommended diagnostic algorithm
Consistent with sarcoidosis:
(Table 1)
Biopsy recommended?
See
PICOs1-3
Biopsy performed?
YES
Negative
YES
NO
Probable
sarcoidosis
Consider
alternative
diagnosis
Not consistent
with sarcoidosis
(Table 2)
Positive and
consistent with
sarcoidosis
(Table 2)
Probable
sarcoidosis
For BHA,
consider biopsy
See PICO 1
Other causes
for granulomas
excluded
(Table 3)
Probable
sarcoidosis
NO
