Disclaimer
This pocket guide a empts to define principles of prac ce that should produce high-quality
pa ent care. It is applicable to specialists, primary care providers and ancillary healthcare
providers. This pocket guide should not be considered exclusive of other methods of care
reasonably directed at obtaining the same results. The ul mate judgment concerning the
propriety of any course of conduct must be made by the clinician a er considera on of each
individual pa ent situa on.
Neither IGC, SITC, nor the authors endorse any product or service associated with the
distributor of this clinical reference tool.
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SITCHNS1973
Defini on of Evidence Grades
Category Defini on Consensus that the interven on is appropriate
1 high-level evidence Uniform
2a lower-level evidence Uniform
2b lower-level evidence General
3 any level of evidence
Consensus ≥75% agreement
✔
Abbrevia ons
CPS, combined posi ve score; CR, complete response; cSCC, cutaneous squamous
cell carcinoma; CT, chemotherapy; EBV, Epstein-Barr virus; FDA, U.S. Food and Drug
Administra on; HNSCC, squamous cell carcinoma of the head and neck; HPV, human
papilloma virus; ICI, immune checkpoint inhibitor; IHC, immunohistochemistry; IO,
Immuno-Oncology MSI, microsatellite instability; NCCN, Na onal Comprehensive Cancer
Network; NPC; nasopharyngeal carcinoma; PD-1, programmed cell death 1; PD-L1,
programmed cell death ligand 1
Source
Ezra E.W. Cohen, R. Bryan Bell, Carlo B. Bifulco, Barbara Burtness, Maura L. Gillison, Kevin
J. Harrington, Quynh-Thu Le, Nancy Y. Lee, Rom Leidner, Rebecca L. Lewis, Lisa Licitra,
Hisham Mehanna, Loren K. Mell, Adam Raben, Andrew G. Sikora, Ravindra Uppaluri,
Fernanda Whitworth, Dan P. Zandberg, Robert L. Ferris. The Society for Immunotherapy
of Cancer consensus statement on immunotherapy for the treatment of squamous cell
carcinoma of the head and neck (HNSCC). J Immunother Cancer. 2019 Jul 15;7(1):184.
